I had a bit of trouble deciphering the MSDN article below:
What MSDN says about using credentials i.e the SmtpClient.Credentials property
Using a username and password with the new .net mailer is actually quite easy (C#):
SmtpClient mailer = new SmtpClient();
mailer.Host = "mail.youroutgoingsmtpserver.com";
mailer.Credentials = new System.Net.NetworkCredential("yourusername", "yourpassword");
mailer.Send("email@example.com", "firstname.lastname@example.org", "Subject line", "Main email text body");
As a sidenote, I was trying to send from an smtp server that was running on the same system as the site I was working on. That server uses the no-ip service to redirect the domain name to the dynamic IP the server sits at. The problem I ran into was that hotmail totally rejected the sent messages on receipt. I could send them ok but they just never came through on the other end, at the hotmail recipient. It took a lot of digging around for me to find out that it rejects mail sent from certain dynamic IP hosts such as no-ip. If you want to send it then you will have to use an smtp server that is NOT with one of these hosts.